Randomized trials of exercise, diet, and weight management interventions for cancer survivors have shown these interventions have the potential to improve quality of life and reduce symptoms and treatment-related adverse health outcomes. Observational studies have also related inactivity and excess weight to increased risk of recurrence and second cancers and to reduced survival. Synthesis of this evidence has resulted in several clinical practice guidelines and policy statements from the American Cancer Society, American Society of Clinical Oncology, American College of Sports Medicine, and others that highlight the need for these interventions for all cancer survivors. Despite these guidelines, knowledge of the importance of these interventions for cancer survivors is low for survivors and clinicians, few survivors are engaging in healthy behaviors consistent with the guidelines, and programs to help survivors make healthy behavior changes are not widely available. This talk will review research, practice, and policy-level initiatives that have launched in the United States to make personalized lifestyle prescription the standard of care for cancer survivors and help survivors make lasting behavior changes.